LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in osteosarcoma. Issue 6 (16th November 2018)

• Record Type: Journal Article
• Authors: Huang, Qiang; Yang, Jiao; He, Xin; Shi, Shuyan; Xing, Shuxing
• Is Part Of: Bioscience reports. Volume 38:Issue 6(2018)
• Publication Date: 2018-11-16
• Subjects: BDNF-AS -- biomarker -- large intervening non-coding RNA -- osteosarcoma; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20181498
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract : Long non-coding RNA (LncRNA) brain-derived neurotrophic factor antisense (BDNF-AS) has been found to be down-regulated and function in a tumor suppressive role in human cancers. However, the expression status and function of BDNF-AS is still unknown in osteosarcoma (OS). In our study, BDNF-AS expression was found to be decreased in OS tissues and cells. Moreover, BDNF-AS low expression was correlated with advanced Enneking stage, large tumor size and poor prognosis in OS patients. The multivariate analysis suggested low expression of BDNF-AS was an independent unfavorable prognostic factor for overall survival in OS patients. The in vitro studies indicated that BDNF-AS overexpression inhibits OS cell proliferation and promotes cell apoptosis through regulating cleaved caspase-3. In conclusion, BDNF-AS serves as a tumor suppressive lncRNA in OS.