Control of HIV-1 gene expression by SR proteins. (19th October 2016)

• Record Type: Journal Article
• Authors: Mahiet, Charlotte; Swanson, Chad M.
• Is Part Of: Biochemical Society transactions. Volume 44:Number 5(2016)
• Page Start: 1417
• Page End: 1425
• Publication Date: 2016-10-19
• Subjects: alternative splicing -- eukaryotic gene expression -- HIV -- RNA metabolism -- SR proteins; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20160113
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Cellular proteins are required for all steps of human immunodeficiency virus type 1 (HIV-1) gene expression including transcription, splicing, 3′-end formation/polyadenylation, nuclear export and translation. SR proteins are a family of cellular RNA-binding proteins that regulate and functionally integrate multiple steps of gene expression. Specific SR proteins are best characterised for regulating HIV-1 RNA splicing by binding specific locations in the viral RNA, though recently they have also been shown to control transcription, 3′-end formation, and translation. Due to their importance in regulating HIV-1 gene expression, SR proteins and their regulatory factors are potential antiviral drug targets.