Endogenous protection against the 6-OHDA model of Parkinson's disease in the Amazonian rodent Proechimys. (14th September 2019)

• Record Type: Journal Article
• Authors: Guimarães Marques, Marcia Jonathas; Real, Caroline Cristiano; Victorino, Daniella Balduino; Britto, Luiz Roberto; Cavalheiro, Esper Abrão; Scorza, Fulvio Alexandre; Ferraz, Henrique Ballalai; Scorza, Carla Alessandra
• Is Part Of: Neuroscience letters. Volume 709(2019)
• Publication Date: 2019-09-14
• Subjects: Neuroprotection -- Parkinson´s disease -- Proechimys -- 6-hydroxydopamine; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2019.134381
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Tyrosine hydroxylase expression did not change following 6−OHDA injection. 6−OHDA unilateral injections did not change exploratory behavior of Proechimys . Proechimys was resistant to dopaminergic neurodegeneration induced by 6−OHDA. Proechimys represents a promising model for studying neurodegenerative disorders. Abstract: Background: Proechimys, an epilepsy-resistant rodent from Amazon Rainforest, is a promising alternative animal model for studying neurodegenerative disorders. Objectives: To evaluate behavioral and immunohistological changes in Proechimys after 6−OHDA-induced model of PD. Methods: Following unilateral injections of 6−OHDA into striatum, animals were assessed for exploratory behavior using the cylinder test. Brain sections were submitted to immunohistochemistry for tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), and ionized calcium-binding adaptor molecule 1 (Iba-1). Results: We observed normal exploratory behavior during cylinder test in all animals. We could not detect changes in the expression of TH in both striatum and SNc, suggesting that Proechimys is resistant to dopaminergic neuronal degeneration. Glial activation was observed by an increase in Iba-1 expression in both striatum and SNc, and by an increase in GFAP expression in striatum. Conclusions: Proechimys represents a promising animal model for studying the mechanisms underlying the susceptibility of dopaminergic neurons to degeneration induced by 6−OHDA.