RecQ and Fe–S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions. (22nd December 2017)

• Record Type: Journal Article
• Authors: Estep, Katrina N.; Brosh, Robert M.
• Is Part Of: Biochemical Society transactions. Volume 46:Number 1(2018)
• Page Start: 77
• Page End: 95
• Publication Date: 2017-12-22
• Subjects: cancer -- DNA replication and recombination -- DNA synthesis and repair -- genetic disease -- genome integrity -- helicase; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20170044
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Helicases are molecular motors that play central roles in nucleic acid metabolism. Mutations in genes encoding DNA helicases of the RecQ and iron–sulfur (Fe–S) helicase families are linked to hereditary disorders characterized by chromosomal instabilities, highlighting the importance of these enzymes. Moreover, mono-allelic RecQ and Fe–S helicase mutations are associated with a broad spectrum of cancers. This review will discuss and contrast the specialized molecular functions and biological roles of RecQ and Fe–S helicases in DNA repair, the replication stress response, and the regulation of gene expression, laying a foundation for continued research in these important areas of study.