Effect of ZnO reinforcement on the compressive properties, in vitro bioactivity, biodegradability and cytocompatibility of bone scaffold developed from bovine bone-derived HAp and PMMA. Issue 16 (November 2019)

• Record Type: Journal Article
• Authors: Barua, Emon; Deoghare, Ashish B.; Chatterjee, Sushovan; Sapkal, Pranav
• Is Part Of: Ceramics international. Volume 45:Issue 16(2019)
• Page Start: 20331
• Page End: 20345
• Publication Date: 2019-11
• Subjects: B. Composite bone scaffold -- D. Hydroxyapatite -- D. Zinc oxide -- D. PMMA -- A. Gas foaming process -- C. In vitro cytotoxicity; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2019.07.006
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: In this study, the effect of zinc oxide (ZnO) incorporation on the properties of Hydroxyapatite (HAp)/Poly(methyl methacrylate) (PMMA)/ZnO based composite bone scaffold is investigated. HAp is derived from calcination of bovine bone bio-waste and ZnO is synthesized by direct precipitation technique. Porous scaffolds are developed by gas foaming process using ammonium bicarbonate as the foaming agent and adding ZnO nanoparticles (NPs) at 2.5, 5, 7.5 and 10% (w/w) respectively. Incorporation of ZnO up to 5% (w/w) is found to significantly enhance the porosity, compressive strength, thermal stability and swelling properties of the developed scaffolds. In-vitro bioactivity and biodegradability assessment using simulated body fluid (SBF) show improved results of 5% ZnO loaded scaffolds. Furthermore, the composite scaffold show enhanced cytocompatibility during the in vitro cytotoxicity test performed using XTT assay. A comprehensive study on the scaffold properties shows that 5% ZnO composite scaffold exhibits the best-optimized properties suitable for bone tissue engineering applications. Graphical abstract: Image 1