Ipso-Bromination/iodination of arylboronic acids: Poly(4-vinylpyridine)-Br2/I2 complexes as safe and efficient reagents. Issue 38 (19th September 2019)

• Record Type: Journal Article
• Authors: Fu, Fang; Gurung, Laxman; Czaun, Miklos; Mathew, Thomas; Prakash, G.K. Surya
• Is Part Of: Tetrahedron letters. Volume 60:Issue 38(2019)
• Publication Date: 2019-09-19
• Subjects: Poly(4-vinylpyridine) -- ipso-Halogenation -- Arylboronic acid -- N-Halosuccinimide; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151020
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Stable poly(4-vinylpyridine)-Br2 /I2 complexes. Shelf stable electrophilic halogenating reagents. Facile ipso -bromination/iodination of aryl boronic acids. Mild reaction conditions tolerating various functional groups. Abstract: Poly(4-vinyl pyridine) supported bromine/iodine complexes were prepared and probed for ipso -bromination/iodination of arylboronic acids. These solid complexes with catalytic amount of additive are found to be safe and efficient reagent system for the ipso -bromination/iodination. The reaction occurs under mild conditions and tolerates various functional groups resulting in products with high selectivity and yields.