Acetoxylation and Halogenation of 2‐Arylbenzoxazinones via Palladium‐Catalyzed C(sp2)‐H Bond Oxidation. Issue 32 (28th August 2019)

• Record Type: Journal Article
• Authors: Vu, Huu Manh; Chen, Fei‐Wu; Li, Xu‐Qin
• Is Part Of: ChemistrySelect. Volume 4:Issue 32(2019)
• Page Start: 9465
• Page End: 9469
• Publication Date: 2019-08-28
• Subjects: 2-Arylbenzoxazinones -- Acetoxylation -- C−H oxidation -- Halogenation -- Palladium; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201902611
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Methods of selective synthesis of C−H acetoxylated and halogenated 2‐arylbenzoxazinones were developed. The reactions went smoothly under the benign conditions and gave the corresponding products with high selectivity. The methods are compatible to the 2‐arylbenzoxazinones with either electron‐withdrawing or electron‐donating groups. Additionally, this transformation can also be scaled up to the gram level. This strategy allows for direct preparation of products, thus providing a good complement to previous C−H oxidations and expanding the field of benzoxazinone as Directing Groups. Abstract : Methods of selective synthesis of C−H acetoxylated and halogenated 2‐arylbenzoxazinones were developed. The reactions went smoothly under the benign conditions and gave the corresponding products with high selectivity. The methods are compatible to the arylbenzoxazinones with either electron‐withdrawing or electron‐donating groups. Additionally, this transformation can also be scaled up to the gram level. This strategy allows for direct preparation of products, thus providing a good complement to previous C−H oxidations and expanding the field of benzoxazinone as Directing Groups.