A nonparametric Bayesian basket trial design. Issue 5 (28th May 2018)
- Record Type:
- Journal Article
- Title:
- A nonparametric Bayesian basket trial design. Issue 5 (28th May 2018)
- Main Title:
- A nonparametric Bayesian basket trial design
- Authors:
- Xu, Yanxun
Müller, Peter
Tsimberidou, Apostolia M.
Berry, Donald - Abstract:
- Abstract: Targeted therapies on the basis of genomic aberrations analysis of the tumor have shown promising results in cancer prognosis and treatment. Regardless of tumor type, trials that match patients to targeted therapies for their particular genomic aberrations have become a mainstream direction of therapeutic management of patients with cancer. Therefore, finding the subpopulation of patients who can most benefit from an aberration‐specific targeted therapy across multiple cancer types is important. We propose an adaptive Bayesian clinical trial design for patient allocation and subpopulation identification. We start with a decision theoretic approach, including a utility function and a probability model across all possible subpopulation models. The main features of the proposed design and population finding methods are the use of a flexible nonparametric Bayesian survival regression based on a random covariate‐dependent partition of patients, and decisions based on a flexible utility function that reflects the requirement of the clinicians appropriately and realistically, and the adaptive allocation of patients to their superior treatments. Through extensive simulation studies, the new method is demonstrated to achieve desirable operating characteristics and compares favorably against the alternatives.
- Is Part Of:
- Biometrical journal. Volume 61:Issue 5(2019:Sep.)
- Journal:
- Biometrical journal
- Issue:
- Volume 61:Issue 5(2019:Sep.)
- Issue Display:
- Volume 61, Issue 5 (2019)
- Year:
- 2019
- Volume:
- 61
- Issue:
- 5
- Issue Sort Value:
- 2019-0061-0005-0000
- Page Start:
- 1160
- Page End:
- 1174
- Publication Date:
- 2018-05-28
- Subjects:
- basket trials -- Bayesian adaptive designs -- subpopulation identification -- targeted therapies
Biometry -- Periodicals
Medical statistics -- Periodicals
570.15195 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4036 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/bimj.201700162 ↗
- Languages:
- English
- ISSNs:
- 0323-3847
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 2087.990000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 11637.xml