Integrating Fluorinated Polymer and Manganese‐Layered Double Hydroxide Nanoparticles as pH‐activated 19F MRI Agents for Specific and Sensitive Detection of Breast Cancer. Issue 36 (22nd July 2019)

• Record Type: Journal Article
• Authors: Zhang, Cheng; Li, Li; Han, Felicity Y.; Yu, Xinying; Tan, Xiao; Fu, Changkui; Xu, Zhi Ping; Whittaker, Andrew K.
• Is Part Of: Small. Volume 15:Issue 36(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-07-22
• Subjects: activated agents -- breast cancer -- contrast agents -- fluorine magnetic resonance imaging -- paramagnetic relaxation enhancement; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201902309
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: 19 F magnetic resonance imaging ( 19 F MRI) agents capable of being activated upon interactions with cancer triggers are attracting increasing attention, although challenges still remain for precise and specific detection of cancer tissues. In this study, a novel hybrid 19 F MRI agent for pH‐sensitive detection of breast cancer tissues is reported, a composite system designed by conjugating a perfluoropolyether onto the surface of manganese‐incorporated layered double hydroxide (Mn‐LDH@PFPE) nanoparticles. The 19 F NMR/MRI signals from aqueous solutions of Mn‐LDH@PFPE nanoparticles are quenched at pH 7.4, but "turned on" following a reduction in pH to below 6.5. This is due to partial dissolution of Mn 2+ from the Mn‐LDH nanoparticles and subsequent reduction in the effect of paramagnetic relaxation. Significantly, in vivo experiments reveal that an intense 19 F MR signal can be detected only in the breast tumor tissue after intravenous injection of Mn‐LDH@PFPE nanoparticles due to such a specific activation. Thus pH‐activated Mn‐LDH@PFPE nanoparticles are a potential "smart" 19 F MRI agent for precise and specific detection of cancer diseases. Abstract : Fluorinated manganese‐based layered double hydroxide nanoparticles are prepared as pH‐activated 19 F MRI agents for specific and sensitive detection of breast cancer cells. The well‐defined nanoparticles can be detected only in breast tumor tissue with negligible 19 F MRI signal observed from other organs. The findings have deep implications for the future development of selective "smart" 19 F MRI agents.