Relationship between viability and genotoxic effect of gamma rays delivered at different dose rates in somatic cells of Drosophila melanogaster. Issue 13 (3rd July 2019)

• Record Type: Journal Article
• Authors: Jiménez, Elizabeth; Pimentel, Emilio; Cruces, Martha P.; Amaya-Chavez, Araceli
• Is Part Of: Journal of toxicology and environmental health. Volume 82:Issue 13(2019)
• Page Start: 741
• Page End: 751
• Publication Date: 2019-07-03
• Subjects: Somatic mutation -- D. melanogaster -- Radiation dose rate -- larvae-viability -- Gamma rays; Toxicology -- Periodicals; Environmental health -- Periodicals; 615.90205
• DOI: 10.1080/15287394.2019.1646681
• Languages: English
• ISSNs: 1528-7394

Abstract

ABSTRACT: The role of dose rate (DR) on biological effects of ionizing radiation is an area of significant research focus and relevant to environmental exposures. The present investigation was aimed to examine the direct relationship between viability and genotoxicity in Drosophila melanogaster, induced by gamma rays in a range of doses from 2 to 35 Gy administered at three different DR. Results indicated that larval-adult viability was reduced in relation to dose but not DR. No marked differences were found in the LD50 produced by differing DR tested. Frequencies of somatic mutation and recombination increased in direct correlation with dose and DR. Data demonstrate the importance of determination of the relationship between viability and genotoxicity induced by DR in in vivo systems for toxicological and radioprotection studies.