Poly(2-oxazoline)-based nanoparticles with aggregation-induced emission (AIE) for targeted cell imaging. Issue 18 (12th December 2019)

• Record Type: Journal Article
• Authors: Zhang, Huaihong; Sun, Yu; Zhou, Tao; Yu, Qing; Yang, Zhenqing; Cai, Zhaosheng; Cang, Hui
• Is Part Of: International journal of polymeric materials. Volume 68:Issue 18(2019)
• Page Start: 1079
• Page End: 1088
• Publication Date: 2019-12-12
• Subjects: Aggregation-induced emission -- poly(2-oxazoline) -- targeted cell imaging; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2018.1525550
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: Poly(2-oxazoline)-based nanoparticles with AIE feature were prepared for targeted cell imaging. First, P(EtOx-BuOx) was fabricated by subsequent cationic ring-opening polymerization (CROP). Then, the folate was attached to the end chains of P(EtOx-BuOx). AIE-active TPEMN was conjugated to the side chains of P(EtOx-BuOx) through ''thio-ene'' click reactions. Cellular experiments demonstrated that the nanocomposites had well dispersity in the physiological environment and could be internalized by folate receptor (FR)-positive cells. We envision that this research endows a simple approach to the fabrication of stable fluorescent polymeric nanocomposites, which display favorable biocompatibility and immense potential for applications in biological imaging and cell detection. Graphical Abstract: