Direct thiocarbamation of imidazoheterocycles via dual C–H sulfurization. Issue 34 (13th August 2019)

• Record Type: Journal Article
• Authors: Deng, Jian-Chao; Zhang, Jun-Rong; Li, Ming-Hua; Huang, Jie-Cheng; Lai, Zhi-Sheng; Tong, Xin-Yu; Cui, Zi-Ning; Tang, Ri-Yuan
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 34(2019)
• Page Start: 7854
• Page End: 7857
• Publication Date: 2019-08-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob01403a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Direct thiocarbamation via dual C–H sulfurization. Abstract : A copper-catalyzed DTBP oxidative dual C–H sulfurization has been developed for the direct thiocarbamation of imidazopyridines using a combination of elemental sulfur and formamides as carbamothioyl surrogates. NBS (bromo succinimide) was found to promote the thiocarbamation in good yields. This dual C–H sulfurization strategy enables access to a wide range of carbamothioyl imidazoheterocycles without the use of highly toxic phosgene.