C–H alkenylation/cyclization and sulfamidation of 2-phenylisatogens using N-oxide as a directing group. Issue 71 (20th August 2019)

• Record Type: Journal Article
• Authors: Guo, Lingmei; Tang, Baolan; Nie, Ruifang; Liu, Yanzhao; Lv, Shan; Wang, Huijing; Guo, Li; Hai, Li; Wu, Yong
• Is Part Of: Chemical communications. Volume 55:Issue 71(2019)
• Page Start: 10623
• Page End: 10626
• Publication Date: 2019-08-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc05719f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Ru(ii )-Catalyzed C–H alkenylation/cyclization and Ir(iii )-catalyzed C–H sulfamidation provided indol-3-one derivatives and sulfamidated 2-phenylisatogens respectively, with good yields and excellent functional group tolerance. Abstract : The first example of transition-metal-catalyzed C–H activations of 2-phenylisatogens with alkynes and sulfonyl azides has been developed using N -oxide as the directing group. Ru(ii )-Catalyzed C–H alkenylation/cyclization and Ir(iii )-catalyzed direct C–H sulfamidation proceeded with good yields and excellent functional group tolerance. Importantly, these two transformations provided straightforward routes for the synthesis of indol-3-one derivatives and sulfamidated 2-phenylisatogens respectively, which might be of considerable bioactivities.