Facile synthesis of substituted quinolines by iron(iii)-catalyzed cascade reaction between anilines, aldehydes and nitroalkanes. Issue 34 (15th August 2019)

• Record Type: Journal Article
• Authors: Mahato, Sachinta; Mukherjee, Anindita; Santra, Sougata; Zyryanov, Grigory V.; Majee, Adinath
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 34(2019)
• Page Start: 7907
• Page End: 7917
• Publication Date: 2019-08-15
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob01294j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A library of substituted quinolines has been synthesized by the reaction of aldehydes, anilines and nitroalkanes using a catalytic amount of Fe(iii ) chloride. Abstract : A library of substituted quinolines has been synthesized by the reaction of aldehydes, anilines and nitroalkanes using a catalytic amount of Fe(iii ) chloride. The reaction is a simple, efficient, one-pot, three-component domino strategy in ambient air which afforded the products in high yields. A probable pathway of the reaction is a sequential aza-Henry reaction/cyclization/denitration. The use of commercially available chemicals as starting materials, an inexpensive metal catalyst, aerobic reaction conditions, tolerance of a wide range of functional groups, and operational simplicity are the notable advantages of this present protocol.