Development of Gold-PAGE: towards the electrophoretic analysis of sulphurous biopolymers. Issue 34 (31st July 2019)

• Record Type: Journal Article
• Authors: Taylor, Emerald R.; Cavuoto, Silvia; Beal, David M.; Caujolle, Sophie; Podoleanu, Adrian; Serpell, Christopher J.
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 34(2019)
• Page Start: 5156
• Page End: 5160
• Publication Date: 2019-07-31
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb00665f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Gold nanoparticles, encapsulated within polyacrylamide electrophoresis gels, can discriminate between number of type of sulphur modifications in DNA strands. Abstract : The prevalence, distinctive reactivity and biological significance of sulphur-based groups in proteins and nucleic acids means that analysis of sulphur is of prime importance in biochemistry, biotechnology, and medicine. We report steps in the development of a method to aid in the detection of these moieties using gold nanoparticles as adjuncts in polyacrylamide gel electrophoresis (Gold-PAGE).