New α-pyrones from an endophytic fungus, Hypoxylon investiens J2. Issue 47 (2nd September 2019)

• Record Type: Journal Article
• Authors: Yuan, Chao; Yang, Hong-Xia; Guo, Yu-Hua; Fan, Lin; Zhang, Ying-Bo; Li, Gang
• Is Part Of: RSC advances. Volume 9:Issue 47(2019)
• Page Start: 27419
• Page End: 27423
• Publication Date: 2019-09-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra05308e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Four new α-pyrones, hypotiens A–D (1–4 ), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera . Abstract : Four new α-pyrones, hypotiens A–D (1–4 ), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera . Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds1–4 are new α-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain. Their plausible biosynthetic pathway was discussed. Biological assay indicated that compounds1–4 showed no antimicrobial, quorum sensing inhibitory, and cytotoxic activities. The specific side chain in α-pyrone derivatives1–4 might be responsible for the weak pharmacological activities.