Transcribing Memories in Genome Architecture. Issue 9 (September 2019)

• Record Type: Journal Article
• Authors: Tonn Eisinger, Katherine R.; West, Anne E.
• Is Part Of: Trends in neurosciences. Volume 42:Issue 9(2019)
• Page Start: 565
• Page End: 566
• Publication Date: 2019-09
• Subjects: transcription -- chromatin -- learning; Neurology -- Periodicals; Neurophysiology -- Periodicals; Neurobiology -- Periodicals; 612.8
• DOI: 10.1016/j.tins.2019.06.002
• Languages: English
• ISSNs: 0166-2236

Abstract

Abstract : Whether dynamic changes in genome architecture underlie transcriptional and functional plasticity in mature neurons has been technically challenging to address. A recent study (Yamada et al ., Nature, 2019) exploited experimental advantages of the cerebellum to reveal cell type-specific changes in chromatin architecture that coordinate neural activity-induced changes in gene transcription and contribute to sensorimotor learning.