Membrane retrieval, recycling and release pathways that organise and sculpt the ciliary membrane. (August 2019)

• Record Type: Journal Article
• Authors: Carter, Stephen P; Blacque, Oliver E
• Is Part Of: Current opinion in cell biology. Volume 59(2019)
• Page Start: 133
• Page End: 139
• Publication Date: 2019-08
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2019.04.007
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract : The microtubule-based cilium that extends from the surface of most eukaryotic cell types serves motility, sensory reception and cell–cell signaling functions, and is disrupted in wide-ranging ciliopathy disorders. The cilium is heavily reliant on dynamic and tuneable intracellular trafficking systems such as intraflagellar transport and Golgi-derived secretory pathways, which control the organelle's structure, function and molecular composition. More recently, endosomal retrieval and recycling, as well as extracellular vesicle (EV) release, pathways have been associated with ciliary membrane control. Here, we discuss the emerging role of these pathways in the control of ciliary membrane homeostasis. The new findings provide a deeper and more integrated understanding of how the ciliary membrane is organised.