Both "canonical" and "immunological" preeclampsia subtypes demonstrate changes in placental immune cell composition. (August 2019)

• Record Type: Journal Article
• Authors: Leavey, Katherine; Grynspan, David; Cox, Brian J.
• Is Part Of: Placenta. Volume 83(2019)
• Page Start: 53
• Page End: 56
• Publication Date: 2019-08
• Subjects: Immune cells -- Immunohistochemistry -- Placenta -- Preeclampsia -- Subtypes; CD cluster of differentiation -- IVS intervillous space -- MPO myeloperoxidase -- PE preeclampsia; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2019.06.384
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Our prior work investigating the heterogeneity of preeclampsia identified multiple placental subtypes of this disorder, including a "canonical" group with maternal vascular malperfusion and an "immunological" group with signs of allograft rejection. Here, we perform a pilot immunohistochemistry study to investigate if an increase in infiltrating maternal immune cells is contributing to the "immunological" pathology subtype. This revealed an enrichment of monocytes and/or neutrophils (CD68 + and MPO + cells) in the intervillous space of these placentas. Surprisingly, "canonical" samples also demonstrated a significant result, with decreased CD68 staining. As such, further immunohistochemistry to assess immune contributions in preeclampsia subtypes is warranted. Highlights: Immune cell-specific genes are upregulated in "immunological" PE placentas. Immunohistochemistry confirmed the increased presence of monocytes and neutrophils. Surprisingly, "canonical" PE placentas revealed decreased monocytes/macrophages.