Novel and Efficient Access to Flavones under Mild Conditions: Aqueous HI‐Mediated Cascade Cyclization/Oxidative Radical Reaction of 2‐Propynolphenols. Issue 40 (15th October 2018)

• Record Type: Journal Article
• Authors: Song, Xian‐Rong; Li, Ren; Yang, Tao; Chen, Xi; Ding, Haixin; Xiao, Qiang; Liang, Yong‐Min
• Is Part Of: European journal of organic chemistry. Issue 40(2018)
• Page Start: 5548
• Page End: 5552
• Publication Date: 2018-10-15
• Subjects: 2‐Propynolphenols -- Cascade cyclization -- Flavones -- Brønsted acids -- Synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201801154
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Herein we disclose a metal‐free and efficient method for the direct conversion of 2‐propynolphenols to biologically important flavones using aqueous HI as the promoter. This transformation was proved via 4‐iodo‐2 H ‐chromenes intermediate, which was simultaneously conversed to corresponding flavones by a Csp2 −I bond cleavage and a C–O bond formation under air. Abstract : Herein we disclose a metal‐free and efficient method for the direct conversion of 2‐propynolphenols to biologically important flavones using aqueous HI as the promoter. This transformation was proved via 4‐iodo‐2 H ‐chromenes intermediate, which was simultaneously conversed to corresponding flavones by a Csp2 –I bond cleavage and a C–O bond formation under air.