Being in a loop: how long non-coding RNAs organise genome architecture. Issue 1 (9th April 2019)

• Record Type: Journal Article
• Authors: Pisignano, Giuseppina; Pavlaki, Ioanna; Murrell, Adele
• Editors: Gilbert, Nick; Allan, James
• Is Part Of: Essays in biochemistry. Volume 63:Issue 1(2019)
• Page Start: 177
• Page End: 186
• Publication Date: 2019-04-09
• Subjects: chromatin architecture -- large intervening non-coding RNA -- transciption; Biochemistry -- Periodicals; 572
• DOI: 10.1042/EBC20180057
• Languages: English
• ISSNs: 0071-1365

Abstract

Abstract : Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [ Genes Dev. (2005)19, 1635–1655; PLoS ONE (2007)2, e1182; Nat. Genet. (2002)30, 329–334]. Long non-coding RNAs (lncRNAs) are able to control chromatin structure through nucleosome positioning, interaction with chromatin re-modellers and chromosome looping. These functions are carried out in cis at the site of lncRNAs transcription or in trans at distant loci. While the evidence for a role in lncRNAs in regulating gene expression through chromatin interactions is increasing, there is still very little conclusive evidence for a potential role in looping organisation. Here, we review models for the involvement of lncRNAs in genome architecture and the experimental evidence to support them.