Adaptive innate immunity or innate adaptive immunity?. (17th July 2019)
- Record Type:
- Journal Article
- Title:
- Adaptive innate immunity or innate adaptive immunity?. (17th July 2019)
- Main Title:
- Adaptive innate immunity or innate adaptive immunity?
- Authors:
- Černý, Jan
Stříž, Ilja - Abstract:
- Abstract : The innate immunity is frequently accepted as a first line of relatively primitive defense interfering with the pathogen invasion until the mechanisms of 'privileged' adaptive immunity with the production of antibodies and activation of cytotoxic lymphocytes 'steal the show'. Recent advancements on the molecular and cellular levels have shaken the traditional view of adaptive and innate immunity. The innate immune memory or 'trained immunity' based on metabolic changes and epigenetic reprogramming is a complementary process insuring adaptation of host defense to previous infections. Innate immune cells are able to recognize large number of pathogen- or danger- associated molecular patterns (PAMPs and DAMPs) to behave in a highly specific manner and regulate adaptive immune responses. Innate lymphoid cells (ILC1, ILC2, ILC3) and NK cells express transcription factors and cytokines related to subsets of T helper cells (Th1, Th2, Th17). On the other hand, T and B lymphocytes exhibit functional properties traditionally attributed to innate immunity such as phagocytosis or production of tissue remodeling growth factors. They are also able to benefit from the information provided by pattern recognition receptors (PRRs), e.g. γδT lymphocytes use T-cell receptor (TCR) in a manner close to PRR recognition. Innate B cells represent another example of limited combinational diversity usage participating in various innate responses. In the view of current knowledge, theAbstract : The innate immunity is frequently accepted as a first line of relatively primitive defense interfering with the pathogen invasion until the mechanisms of 'privileged' adaptive immunity with the production of antibodies and activation of cytotoxic lymphocytes 'steal the show'. Recent advancements on the molecular and cellular levels have shaken the traditional view of adaptive and innate immunity. The innate immune memory or 'trained immunity' based on metabolic changes and epigenetic reprogramming is a complementary process insuring adaptation of host defense to previous infections. Innate immune cells are able to recognize large number of pathogen- or danger- associated molecular patterns (PAMPs and DAMPs) to behave in a highly specific manner and regulate adaptive immune responses. Innate lymphoid cells (ILC1, ILC2, ILC3) and NK cells express transcription factors and cytokines related to subsets of T helper cells (Th1, Th2, Th17). On the other hand, T and B lymphocytes exhibit functional properties traditionally attributed to innate immunity such as phagocytosis or production of tissue remodeling growth factors. They are also able to benefit from the information provided by pattern recognition receptors (PRRs), e.g. γδT lymphocytes use T-cell receptor (TCR) in a manner close to PRR recognition. Innate B cells represent another example of limited combinational diversity usage participating in various innate responses. In the view of current knowledge, the traditional black and white classification of immune mechanisms as either innate or an adaptive needs to be adjusted and many shades of gray need to be included. … (more)
- Is Part Of:
- Clinical science. Volume 133:Number 14(2019)
- Journal:
- Clinical science
- Issue:
- Volume 133:Number 14(2019)
- Issue Display:
- Volume 133, Issue 14 (2019)
- Year:
- 2019
- Volume:
- 133
- Issue:
- 14
- Issue Sort Value:
- 2019-0133-0014-0000
- Page Start:
- 1549
- Page End:
- 1565
- Publication Date:
- 2019-07-17
- Subjects:
- adaptive immunity -- immunological memmory -- innate immunity -- innate recognition -- trained immunity
Medicine -- Periodicals
Biochemistry -- Periodicals
616 - Journal URLs:
- https://portlandpress.com/clinsci ↗
- DOI:
- 10.1042/CS20180548 ↗
- Languages:
- English
- ISSNs:
- 0143-5221
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 11618.xml