Design and functionalization of bioactive benzoxazines. An unexpected ortho-substitution effect. (12th July 2019)

• Record Type: Journal Article
• Authors: Arendt-Pindel, Agata; Marszałek-Harych, Aleksandra; Gębarowska, Elżbieta; Gębarowski, Tomasz; Jędrzkiewicz, Dawid; Pląskowska, Elżbieta; Zalewski, Dariusz; Gulia, Nurbey; Szafert, Sławomir; Ejfler, Jolanta
• Is Part Of: New journal of chemistry. Volume 43:Number 30(2019)
• Page Start: 12042
• Page End: 12053
• Publication Date: 2019-07-12
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c8nj06440g
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A family of o, p - and N-functionalized dihydro-2 H -benzo-1, 3-oxazines was synthesized and characterized. Abstract : A family of o, p - and N-functionalized dihydro-2 H -benzo-1, 3-oxazines was synthesized and characterized. In vitro antimicrobial activity of the new benzoxazines was assessed against pathogenic fungi and Gram-negative and Gram-positive bacteria. The screened compounds showed significant in vitro antimicrobial effect, but introduction of the bulky substituent in the ortho position of the aryl ring caused a loss of their antibacterial efficacy. Cytotoxic assay results revealed that a molecule containing long alkyl chain substituents offered a remarkable viability of mouse fibroblast cells. Additionally, the liquid nature of alkyl-chain-modified monomers and the high processing windows indicate their high application potential.