Liquid, glass, and crystalline indomethacin studied by Brillouin scattering. (18th April 2018)

• Record Type: Journal Article
• Authors: Shibata, Tomohiko; Kojima, Seiji
• Is Part Of: Japanese journal of applied physics. Volume 57:Number 7(2018)Supplement 1
• Publication Date: 2018-04-18
• Subjects: Physics -- Periodicals; 621.05
• DOI: 10.7567/JJAP.57.07LB03
• Languages: English
• ISSNs: 0021-4922

Abstract

Abstract: Indomethacin (IMC) is a medicine available in various countries worldwide. The longitudinal acoustic (LA) and transverse acoustic (TA) modes of liquid, glass, and γ-form crystalline IMC were studied by Brillouin scattering spectroscopy on the basis of the backward scattering and reflection-induced ΘA scattering geometies. Upon heating of glassy IMC, the elastic anomaly at the liquid–glass transition temperature T g = 315 K was clearly observed. With further heating of the supercooled liquid state, crystallization and melting into an equilibrium liquid phase were also observed. The temperature dependence of the elastic constants of a γ-form IMC crystal was determined using the observed velocities of an LA and two TA modes below the melting temperature T m = 433 K.