Distal Weak Coordination of Acetamides in Ruthenium(II)‐Catalyzed C−H Activation Processes. Issue 3 (12th December 2017)

• Record Type: Journal Article
• Authors: Bu, Qingqing; Rogge, Torben; Kotek, Vladislav; Ackermann, Lutz
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 3(2018)
• Page Start: 765
• Page End: 768
• Publication Date: 2017-12-12
• Subjects: arylacetamides -- density functional theory -- homogeneous catalysis -- mechanisms -- ruthenium; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201711108
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: C−H activations with challenging arylacetamides were accomplished by versatile ruthenium(II) biscarboxylate catalysis. The distal C−H functionalization offers ample scope—including twofold oxidative C−H functionalizations and alkyne hydroarylations—through facile base‐assisted internal electrophilic‐type substitution (BIES) C−H ruthenation by weak O ‐coordination. Abstract : From a distance : A versatile Ru II ‐catalyzed method permits facile distal C−H activation of weakly O‐coordinating arylacetamides via a six‐membered ruthenacycle intermediate. The scope of the reaction includes primary, secondary, and tertiary amides.