Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon. (19th December 2017)
- Record Type:
- Journal Article
- Title:
- Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon. (19th December 2017)
- Main Title:
- Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon
- Authors:
- Su, Fan
Lu, Yandong
Kong, Lingran
Liu, Jingjing
Luo, Tuoping - Abstract:
- Abstract: A new strategy was devised for the total synthesis of highly oxidized ent ‐kauranoids. A highly regio‐ and diastereoselective intermolecular Diels–Alder cycloaddition involving a diene embedded in a substituted bicyclo[4.1.0] skeleton was used to assemble all carbon centers but C17 of the target molecule at an early stage of the synthesis. Subsequent synthetic steps, including redox manipulations, SmI2 ‐mediated cyclization, and isomerization reactions, afforded the antitumor natural product maoecrystal P.
- Is Part Of:
- Angewandte Chemie. Volume 130:Number 3(2018)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 130:Number 3(2018)
- Issue Display:
- Volume 130, Issue 3 (2018)
- Year:
- 2018
- Volume:
- 130
- Issue:
- 3
- Issue Sort Value:
- 2018-0130-0003-0000
- Page Start:
- 768
- Page End:
- 772
- Publication Date:
- 2017-12-19
- Subjects:
- Cycloaddition -- Cyclopropane -- Diterpenoide -- Radikalische Cyclisierung -- Totalsynthese
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201711084 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 11607.xml