The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways. (10th April 2018)

• Record Type: Journal Article
• Authors: Jiang, Danlu; Chen, Sheng; Sun, Ruyu; Zhang, Xue; Wang, Di
• Is Part Of: Cancer letters. Volume 419(2018)
• Page Start: 8
• Page End: 19
• Publication Date: 2018-04-10
• Subjects: NLRP3 inflammasome -- Metabolic disorder -- Metabolic pathway -- IL-1β -- IL-18; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2018.01.034
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells; they mediate the activation of caspase-1, leading to cellular pyroptosis. So far, a variety of studies on inflammasomes have emerged, and the best-studied is the NLRP3 inflammasome that is involved in many inflammatory responses. Furthermore, its relationship with metabolism is gaining increasing attention in this field. In this review, we discuss the importance of the NLRP3 inflammasome in metabolic disorders and its close association with metabolic pathways. Highlights: Roles of NLRP3 inflammasome in various metabolic disorders are discussed. Characters of NLRP3 inflammasome in metabolic pathways are summarized. NLRP3 inflammasome may serve as a potential therapeutic target.