Plasticity of myeloid-derived suppressor cells in cancer. (April 2018)

• Record Type: Journal Article
• Authors: Tcyganov, Evgenii; Mastio, Jerome; Chen, Eric; Gabrilovich, Dmitry I
• Is Part Of: Current opinion in immunology. Volume 51(2018)
• Page Start: 76
• Page End: 82
• Publication Date: 2018-04
• Subjects: Immunology -- Periodicals; Allergy -- Periodicals; Immunology -- Abstracts -- Periodicals; Allergy -- Abstracts -- Periodicals; 616.079
• DOI: 10.1016/j.coi.2018.03.009
• Languages: English
• ISSNs: 0952-7915

Abstract

Highlights: Myeloid-derived suppressor cells (MDSC) are critically important for regulation of immune responses in cancer. MDSC have distinct features separating them from neutrophils and monocytes. Monocytic MDSC differentiate in tumor sites to macrophages and dendritic cells. This process is shaped by tumor microenvironment. In recent years, specific mechanisms regulating M-MDSC differentiation start to emerge. Abstract : In recent years, myeloid-derived suppressor cells (MDSC) have emerged as one of the major inhibitors of immune effector cell function in cancer. MDSC represent a heterogeneous population of largely immature myeloid cells that are characterized by a pathological state of activation and display potent immune suppressive activity. Two major subsets of MDSC have been identified: monocytic (M-MDSC) and polymorphonuclear (PMN-MDSC). PMN-MSDC share phenotypic and morphologic features with neutrophils, whereas M-MDSC are similar to monocytes and are characterized by high plasticity. Differentiation of M-MDSC to macrophages and dendritic cells is shaped by tumor microenvironment. In recent years, the mechanisms of this process start to emerge.