Time- and frequency-domain measures of heart rate variability predict cardiovascular outcome in patients with type 2 diabetes. (September 2018)

• Record Type: Journal Article
• Authors: Cha, Seon-Ah; Park, Yong-Moon; Yun, Jae-Seung; Lee, Seung-Hwan; Ahn, Yu-Bae; Kim, Sung-Rae; Ko, Seung-Hyun
• Is Part Of: Diabetes research and clinical practice. Volume 143(2018)
• Page Start: 159
• Page End: 169
• Publication Date: 2018-09
• Subjects: Cardiac autonomic neuropathy -- Heart rate variability -- Type 2 diabetes -- Cardiovascular outcome; CVD cardiovascular disease -- T2DM type 2 diabetes -- CHD coronary heart disease -- HbA1C glycated hemoglobin -- CV cardiovascular -- CAN cardiovascular autonomic neuropathy -- HRV heart rate variability -- T1DM type 1 diabetes -- AFT autonomic function test -- FPG fasting plasma glucose -- pp2hr postprandial 2 hour glucose -- eGFR estimated glomerular filtration rate -- TP total power -- LF low frequency -- HF high frequency -- SDNN normal-to-normal interval -- RMSSD root mean square of differences between adjacent R-R intervals -- MI myocardial infarction -- WHO World Health Organization -- HR hazard ratio -- CI confidence intervals -- ms millisecond -- ARIC Atherosclerosis risk in communities -- NN normal-to-normal; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2018.07.001
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aims: To evaluate the association between impaired heart rate variability (HRV) and cardiovascular disease (CVD) in patients with type 2 diabetes (T2DM). Methods: A total of 655 patients with T2DM who underwent cardiovascular autonomic function testing were consecutively recruited and followed up prospectively. Time- and frequency-domain HRV were assessed for 5 min by beat-to-beat heart rate recording. We estimated the development of CVD events during a follow-up period. Results: During a median follow-up of 7.8 years, 9.6% (n = 49) of patients developed CVD (10.6 per 1000 patient-years). The mean age and diabetes duration were 54.9 ± 8.6 years and 9.4 ± 7.3 years, respectively. Patients who had cardiovascular autonomic neuropathy (CAN) had decreased HRV compared with those with normal autonomic function. Multivariable cox hazard regression analysis revealed the lowest 10th percentile of the SD of the normal-to-normal interval (HR 2.62; 95% CI 1.30–5.31), total power (HR 2.81; 95% CI 1.37–5.79), low-frequency power (HR 2.68; 95% CI 1.28–5.59), and high-frequency power (HR 2.24; 95% CI 1.09–4.59) were significant predictors for developing CVD in patients with T2DM. Conclusions: Time- and frequency-domain measures of HRV independently predicted cardiovascular outcome in patients with T2DM.