Bioaccessible trace metals in lip cosmetics and their health risks to female consumers. (July 2018)

• Record Type: Journal Article
• Authors: Gao, Peng; Lei, Tingting; Jia, Liming; Yury, Badmatsybenov; Zhang, Zhaohan; Du, Yingqiu; Feng, Yujie; Xing, Baoshan
• Is Part Of: Environmental pollution. Volume 238(2018)
• Page Start: 554
• Page End: 561
• Publication Date: 2018-07
• Subjects: Health risk -- Bioaccessibility -- Trace metal -- In vitro; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2018.03.072
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Females can be exposed to toxic elements in lip cosmetics following ingestion. The bioaccessibility of Cr, Mn, Co, Ni, Cu, Cd, Sb and Pb in lip cosmetics (n = 32) were assessed via the dilute HCl extraction method, In Vitro Gastrointestinal protocol (IVG) and the United States Pharmacopeia Methodology (USPM), and then health risks were characterized. The total concentrations of trace metals (TMs) in lip cosmetics were in the range of 15.55–111.97 mg/kg (Mean: 60.99 mg/kg). Cu, Pb and Cr were the three major TMs and accounting for >75% of the total concentrations. Except Sb and Pb in 4/32 and 4/32 samples were higher than the US FDA (Food and Drug Administration of the United States) limits, the other TMs were lower than that limits. Only bioaccessible Pb in all samples significantly exceeded the FDA limit 0.1 mg/kg in candy. Using IVG or USPM might be preferable for evaluating the TMs exposure over HCl since they better represent gastrointestinal physiology. The estimated average daily intake (ADI) of bioaccessible ∑TMs through lip cosmetics ingestion of career women and female college students were under safety level. The long-term exposure of bioaccessible TMs by lip cosmetics using would inevitably cause non-carcinogenic health risk. This is the first report on the in vitro tests used for evaluating bioaccessible TMs in lip cosmetics. Graphical abstract: Image 1 Highlights: Bioaccessible trace metals (TMs) in lip cosmetics were assessed via In Vitro tests. The ingestions of TMs were evaluated by the standard of those in drinking water. Day-response on various users of the usage frequency was taken in evaluation. Bioaccessible Pb significantly exceeded the FDA limit of 0.1 mg/kg in all samples. Abstract : The exposure of bioaccessible TMs by lip cosmetics using would inevitably cause the non-carcinogenic health risk (day-response).