Maternal dietary intake of polyunsaturated fatty acids modifies association between prenatal DDT exposure and child neurodevelopment: A cohort study. (July 2018)

• Record Type: Journal Article
• Authors: Ogaz-González, Rafael; Mérida-Ortega, Ángel; Torres-Sánchez, Luisa; Schnaas, Lourdes; Hernández-Alcaraz, César; Cebrián, Mariano E.; Rothenberg, Stephen J.; García-Hernández, Rosa María; López-Carrillo, Lizbeth
• Is Part Of: Environmental pollution. Volume 238(2018)
• Page Start: 698
• Page End: 705
• Publication Date: 2018-07
• Subjects: Polyunsaturated fatty acids -- McCarthy scale -- Neurodevelopment -- Prenatal exposure to DDT -- México; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2018.03.100
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Background: Maternal 1, 1-dichloro-2, 2-bis(p-chlorophenyl)ethylene (DDE) serum levels during pregnancy have been negatively linked to child neurodevelopment in contrast to intake of omega-3 and -6 (ω-3 and ω-6) fatty acids. Objectives: To assess whether maternal dietary intake of ω-3 and ω-6 during pregnancy modifies the association between exposure to DDE and child neurodevelopment from age 42–60 months. Methods: Prospective cohort study with 142 mother–child pairs performed in Mexico. DDE serum levels were determined by electron capture gas chromatography. Dietary ω-3 and ω-6 intake was estimated by questionnaire. Child neurodevelopment was assessed by McCarthy Scales. Results: Docosahexaenoic (DHA) fatty acid intake significantly modified the association between DDE and motor component: increased maternal DDE was associated with lower motor development in children whose mothers had lower DHA intake (βlog2DDE = −1.25; 95% CI: −2.62, 0.12), in contrast to the non-significant increase among children whose mothers had higher DHA intake (βlog2DDE-motor = 0.50; 95% CI: 0.55, 1.56 ). Likewise, arachidonic fatty acid (ARA) intake modified the association between DDE and memory component: increased maternal DDE was associated with a significantly larger reduction in the memory component in children whose mothers had lower ARA intake (βlog2DDE = −1.31; 95% CI: −2.29, −0.32) than children whose mothers had higher ARA intake (βlog2DDE-memory = 0.17; 95% CI: −0.78, 1.11). Conclusions: Dietary intake of DHA and ARA during pregnancy may protect against child neurodevelopment damage associated with prenatal maternal DDE levels. Graphical abstract: Image 1 Highlights: DDT is a lipophilic neurotoxic compound with high persistence in the environment. Polyunsaturated fatty acids (PUFAs) are essential neuroprotective nutrients. PUFAs intake antagonize child neurodevelopment damage associated with DDT exposure. Abstract : Dietary intake of some polyunsaturated fatty acids during pregnancy may protect against child neurodevelopment damage associated with prenatal maternal DDE levels.