Targeting autophagy in gastrointestinal malignancy by using nanomaterials as drug delivery systems. (10th April 2018)

• Record Type: Journal Article
• Authors: Raju, G. Seeta Rama; Pavitra, E.; Merchant, Neha; Lee, Hoomin; Prasad, Ganji Lakshmi Vara; Nagaraju, Ganji Purnachandra; Huh, Yun Suk; Han, Young-Kyu
• Is Part Of: Cancer letters. Volume 419(2018)
• Page Start: 222
• Page End: 232
• Publication Date: 2018-04-10
• Subjects: Autophagy -- Nanomaterial -- Gastric cancer -- Pancreatic cancer -- Liver cancer; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2018.01.044
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Autophagy is a conserved catabolic process involving large protein degradation by a ubiquitous autophagosomic signaling pathway, which is essential for cellular homeostasis. It is triggered by environmental factors such as stress, lack of nutrients, inflammation, and eliminating intracellular pathogens. Although the mechanisms underlying autophagy are still unclear, increasing evidence illuminates the magnitude of autophagy in a wide range of physiological processes and human diseases. Simultaneously, research community has focused on the triggering of autophagy by the internalization of engineered nanomaterials, which indicates a new line of revolution in cancer cure. However, most studies on nanoparticle-induced autophagy focus on brain, breast, and cervical cancers; limited reports are available on gastrointestinal (GI) cancers. Therefore, the aim of this mini review is to discuss in detail the role of autophagy in GI malignancy and the status of research on nanoparticle-induced autophagy. Highlights: Role of autophagy in GI growth and metastasis. Autophagy as a new therapeutic target in GI malignancy. Use of nanoparticles as diagnostic and therapeutic agents in GI malignancy. Modulation of autophagy by nanoparticles as drug delivery carriers.