Soluble B7-H3 (sB7-H3) is over-expressed in the serum of type 1 diabetes patients. (September 2018)

• Record Type: Journal Article
• Authors: Fang, Chen; Li, Sicheng; Xu, Rongqin; Guo, Heming; Jiang, Rong; Ding, Sisi; Chen, Xiaohong; Huang, Yun; Hu, Ji; Liu, Cuiping; Tu, Yifeng
• Is Part Of: Diabetes research and clinical practice. Volume 143(2018)
• Page Start: 332
• Page End: 336
• Publication Date: 2018-09
• Subjects: Type 1 diabetes -- B7-H3/CD276 -- Soluble B7-H3 -- Immune checkpoint; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2018.08.004
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Type 1 Diabetes (T1D) is an autoimmune disease resulting from insulin-secreting β-cells mediated by autoreactive T cells. We demonstrated increased level of sB7-H3 in T1D patients than in healthy control group. This result suggests that B7-H3 may be may be a promising biomarker associated with the pathogenesis of T1D.