New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress. (March 2018)

• Record Type: Journal Article
• Authors: Abuammah, Aliah; Maimari, Nataly; Towhidi, Leila; Frueh, Jenny; Chooi, Kok Yean; Warboys, Christina; Krams, Rob
• Is Part Of: Current opinion in biomedical engineering. Volume 5(2018)
• Page Start: 96
• Page End: 104
• Publication Date: 2018-03
• Subjects: Wnt -- Notch -- TGF-β -- Endothelium -- Shear stress -- Mechanotransduction; Biomedical engineering -- Periodicals; 610.28
• DOI: 10.1016/j.cobme.2018.03.003
• Languages: English
• ISSNs: 2468-4511

Abstract

Abstract: Mechanotransduction, the ability of cells to detect and react to mechanical forces, is increasingly playing a critical role in a variety of physiological and pathophysiological processes. While the focus has previously been on the MAPK, NF-ϰB and ROS generating pathways, ancient embryological pathways have reached little attention. Recently, a surge of new studies have been published on these pathways and their role in mechanotransduction and this review paper aims to provide a concise overview on the latest studies and brings them in to a larger perspective. Special emphasis is on the non-canonical aspects of the Wnt, TGF-β and Notch pathways and their role in flow. Highlights: Previously pathways of the domain of embryology (Notch, Wnt, TGF-β) have been shown to be shear sensitive. In particular, their non-canonical variants seem to be important for blood flow related diseases like atherosclerosis. These three pathways seem to be interconnected forming a functional overarching network, which is sensitive to shear stress.