Changes in inflammatory/cardiac markers of HIV positive patients. (January 2018)

• Record Type: Journal Article
• Authors: Rezer, João F.P.; Adefegha, Stephen A.; Ecker, Assis; Passos, Daniela F.; Saccol, Renata S.P.; Bertoldo, Tatiana M.D.; Leal, Daniela B.R.
• Is Part Of: Microbial pathogenesis. Volume 114(2018)
• Page Start: 264
• Page End: 268
• Publication Date: 2018-01
• Subjects: Inflammation -- HIV -- Antiretroviral drug -- E-NTPDase -- E-5′-nucleotidase; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2017.11.045
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: HIV replication promotes atherogenesis and participates in the immune response to the virus, thereby influencing the inflammatory profile. These changes may, in turn, contribute to the risk of cardiovascular diseases with involvement of platelets. However, adenine nucleotides and nucleosides involved in thromboregulation and modulation of immune response may therefore be affected by these alterations. Objectives: This study sought to evaluate the profile of pro and anti-inflammatory cytokines (IL-10, IL-6, IL-17, TNF, IL-4, IL-2 and IFN-gamma), cardiac markers (troponin, CK, CK MB, LDH, CRP) in HIV-positive patients and assess the in vitro effect of antiretroviral therapy on the activities of ectonucleotidases (E-NTPDase and E-5′-nucleotidase) in human platelets. Design and Methods: Blood samples were obtained from ten HIV positive patients at the Infectious Disease Clinic of the University Hospital of Santa Maria, Brazil and ten HIV negative individuals (control group) for this study. Results: The results revealed that there were significant ( P < 0.05) increases in serum levels of IL-6 and IFN-gamma with no significant ( P > 0.05) changes in the serum levels of the cardiac markers investigated (CK, CK-MB, troponin, LDH and CRP). In addition, the ectonucleotidases (E-NTPDase and E-5′-nucleotidase) activities were not altered ( P > 0.05) in human platelets when incubated with different antiretroviral drugs in vitro . Conclusions: The results of this study suggest that, despite successful treatment, a proinflammatory state is not altered in HIV patients, and that antiretroviral therapy per se does not change the purinergic profile. Highlights: Inflammatory markers are altered in HIV treated patients. Changes in cardiac markers were not detected in HIV treated patients. Chronic inflammation remains in successfully treated HIV patients. No association between cytokine levels and biomarkers of myocardial disease was found. Antiretroviral therapy per se does not alter the purinergic profile.