Association between organohalogenated pollutants in cord blood and thyroid function in newborns and mothers from Belgian population. (July 2018)

• Record Type: Journal Article
• Authors: Dufour, Patrice; Pirard, Catherine; Seghaye, Marie-Christine; Charlier, Corinne
• Is Part Of: Environmental pollution. Volume 238(2018)
• Page Start: 389
• Page End: 396
• Publication Date: 2018-07
• Subjects: Newborns -- Perfluorinated compounds -- Organochlorine pesticides -- Polychlorinated biphenyls -- Thyroid; ED endocrine disruptor -- TH thyroid hormone -- T4 thyroxine -- T3 triiodothyronine -- PCB polychlorinated biphenyl -- TTR transthyretin -- TSH thyroid stimulating hormone -- HCB hexachlorobenzene -- DDT dichlorodiphenyltrichloroethane -- PFC perfluorinated compound -- PFOS perfluorooctane sulfonate -- BMI body mass index -- PFHxS perfluorohexane sulfonate -- PFOA perfluorooctanoic acid -- PFNA perfluorononanoic acid -- PFDA perfluorodecanoic acid -- PFUdA perfluoroundecanoic acid -- PFHpA perfluoroheptanoic acid -- ESI electronic negative ionization -- RT retention time -- CV cone voltage -- CE collision energy -- β-HCH β-hexachlorohexane -- 4, 4′-DDE 4, 4′-dichlorodiphenyldichloroethylene -- DF detection frequency; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2018.03.058
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: The last decades have seen the increasing prevalence of thyroid disorders. These augmentations could be the consequence of the increasing contamination of the environment by chemicals that may disrupt the thyroid function. Indeed, in vitro studies have shown that many chemicals contaminating our environment and highlighted in human serum, are able to interfere with the thyroid function. Given the crucial importance of thyroid hormones on neurodevelopment in fetus and newborns, the influence of these pollutants on newborn thyroid homeostasis is a major health concern. Unfortunately, the overall evidence for a deleterious influence of environmental pollutants on thyroid remains poorly studied. Therefore, we assessed the contamination by polychlorinated biphenyls (PCBs), organochlorine pesticides and perfluorinated compounds (PFC) in 221 cord blood samples collected in Belgium between 2013 and 2016. Our results showed that compared to previous studies performed on newborns recruited in Belgium during the two last decades, the present pollutant contamination is declining. Multivariate statistical analyses pointed out a decrease of thyroid stimulating hormone (TSH) level in male newborns with detectable level of 4, 4′- dichlorodiphenyldichloroethylene (4, 4′-DDE) in comparison with those with no detectable level (p = 0.025). We also highlighted a negative association between perfluorononanoic acid (PFNA) concentration and TSH in male newborns ( p = 0.018). Logistic regression showed increased odds ratio for presentation of hypothyroid in mother for each one unit augmentation of log natural concentration of PFOA (OR = 2.30, [1.18–4.5]) and PFOS (OR = 2.03 [1.08–3.83]). Our findings showed that the residual contamination by PFCs and organochlorine pollutants in cord blood are correlated with thyroid hormone in the newborns and the risk of hypothyroid in mothers. Graphical abstract: Image 1 Highlights: The PCB, PFC and organochlorine pesticide contamination in cord blood in Belgium are declining. In male newborns, PFNA and 4, 4′-DDE contamination were negatively correlated to TSH level. PFOA and PFOS higher levels were associated with increased risk of hypothyroid in the mother. Abstract : TSH level in newborns and maternal thyroid status are significantly correlated with the concentration of some persistent organic pollutants in the cord blood.