Prevalence of human T-cell lymphotropic virus type-1 infection among blood donors in mainland China: a systematic review and meta-analysis of the last 20 years. Issue 8 (3rd August 2019)

• Record Type: Journal Article
• Authors: Chen, Xue; Liu, Fang; Fu, Xuemei; Feng, Yi; Zhang, Dingding; Liu, Humin; Xi, Guangxiang; Hu, Jinliang
• Is Part Of: Expert review of hematology. Volume 12:Issue 8(2019)
• Page Start: 579
• Page End: 587
• Publication Date: 2019-08-03
• Subjects: Human T-cell lymphotropic virus type 1 (HTLV-1) -- prevalence -- blood donors -- mainland China -- meta-analysis; Hematology -- Periodicals; 616.15005
• DOI: 10.1080/17474086.2019.1632703
• Languages: English
• ISSNs: 1747-4086

Abstract

ABSTRACT: Background : The southeastern coastal area of China has a high prevalence of HTLV-1 infection among blood donors. However, the estimation of HTLV-1 prevalence on a national and regional level is little known. The aim of this study is to understand and explore the estimation of HTLV-1 infection prevalence among blood donors on a national and regional level in mainland China by using a systematic review and meta-analysis. Study design and methods : All relevant publications of the past two decades (1998–2017), which were reported in both English and Chinese languages, were adopted and systematically assessed. The estimation of prevalence and its 95% confidence interval (CI) at the level of provinces/municipalities and overall were estimated using meta-analysis method. Results : From the 327 studies searched, 60 met the inclusion criteria. These were from 18 provinces and four municipalities and included 1, 420, 079 blood donors. The overall estimation of the HTLV-1 prevalence in blood donors was 0.169‰, and its 95% CI was 0.121‰-0.240‰. Conclusion : A disproportionate distribution of HTLV-1 infection among blood donors in different provinces/municipalities regarding its prevalence has been reported. This study recommends developing appropriate HTLV-1 screening strategies of blood donors in various regions of China considering regional prevalence, and cost-effectiveness.