Interplay between the electrostatic membrane potential and conformational changes in membrane proteins. (10th January 2019)

• Record Type: Journal Article
• Authors: Zhang, Xuejun C.; Li, Hang
• Is Part Of: Protein science. Volume 28:Number 3(2019)
• Page Start: 502
• Page End: 512
• Publication Date: 2019-01-10
• Subjects: membrane protein electrostatics -- membrane protein dynamics -- electrostatic membrane potential -- hydrophobic mismatch force -- amphipathic helix; Proteins -- Periodicals; 572.6
• DOI: 10.1002/pro.3563
• Languages: English
• ISSNs: 0961-8368

Abstract

Abstract: Transmembrane electrostatic membrane potential is a major energy source of the cell. Importantly, it determines the structure as well as function of charge‐carrying membrane proteins. Here, we discuss the relationship between membrane potential and membrane proteins, in particular whether the conformation of these proteins is integrally connected to the membrane potential. Together, these concepts provide a framework for rationalizing the types of conformational changes that have been observed in membrane proteins and for better understanding the electrostatic effects of the membrane potential on both reversible as well as unidirectional dynamic processes of membrane proteins.