Targeted Cancer Therapy: Correlative Light‐Electron Microscopy Shows RGD‐Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Issue 11 (8th June 2016)

• Record Type: Journal Article
• Authors: Othman, Basmah A.; Greenwood, Christina; Abuelela, Ayman F.; Bharath, Anil A.; Chen, Shu; Theodorou, Ioannis; Douglas, Trevor; Uchida, Maskai; Ryan, Mary; Merzaban, Jasmeen S.; Porter, Alexandra E.
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 11(2016)
• Page Start: 1248
• Page End: 1248
• Publication Date: 2016-06-08
• Subjects: cellular targeting -- cytotoxicity -- integrin αvβ3 receptors -- triple negative breast cancer cells -- zinc oxide nanoparticles; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201670053
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : On page 1310 J. S. Merzaban, A. E. Porter, and co‐workers present fluorescently labeled RGD‐targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic ZnO to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light‐electron microscopy shows that NPs dissolve into ionic Zn 2+ (blue) upon uptake and cause apoptosis (red) with intra‐tumor heterogeneity, thereby providing a possible strategy for targeted breast cancer therapy. Cover design by Ivan Gromicho.