Supramolecular Assemblies with Near‐Infrared Emission Mediated in Two Stages by Cucurbituril and Amphiphilic Calixarene for Lysosome‐Targeted Cell Imaging. Issue 38 (23rd August 2018)

• Record Type: Journal Article
• Authors: Chen, Xu‐Man; Chen, Yong; Yu, Qilin; Gu, Bo‐Han; Liu, Yu
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 38(2018)
• Page Start: 12519
• Page End: 12523
• Publication Date: 2018-08-23
• Subjects: amphiphilic calixarenes -- cucurbituril -- lysosome-targeted cell imaging -- near-IR supramolecular assemblies; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201807373
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A two‐stage mediated near‐infrared (NIR) emissive supramolecular assembly for lysosome‐targeted cell imaging is presented. 4, 4′‐Anthracene‐9, 10‐diylbis(ethene‐2, 1‐diyl))bis(1‐ethylpyridin‐1‐ium) bromide (ENDT) was synthesized as an organic dye with weak fluorescence emission at 625 nm. When ENDT complexes with cucurbit[8]uril (CB[8]), this binary supramolecular complex assembles into nanorods with a near‐infrared fluorescence emission (655 nm) and fluorescence enhancement as the first stage. Such supramolecular complexes interact with lower‐rim dodecyl‐modified sulfonatocalix[4]arene (SC4AD) to form nanoparticles for further fluorescence enhancement as the second stage. Furthermore, based on a co‐staining experiment with LysoTracker Blue, such nanoparticles can be applied in NIR lysosome‐targeted cell imaging. Abstract : Supramolecular assemblies were designed with initially weak 625 nm near‐IR emission that was enhanced and shifted to 655 nm in two stages by cucurbit[8]uril (CB[8]) and amphiphilic calixarene SC4AD. This system was used for lysosome‐targeted cell imaging.