Half-life of plasma phytosterols in very low birth weight preterm infants on routine parenteral nutrition with vegetable oil-based lipid emulsions. Issue 1 (February 2018)

• Record Type: Journal Article
• Authors: Pupillo, Daniele; Correani, Alessio; Biagetti, Chiara; D'Ascenzo, Rita; Simonato, Manuela; Verlato, Giovanna; Cogo, Paola; Rocchi, Marco B.L.; Carnielli, Virgilio P.
• Is Part Of: Clinical nutrition. Volume 37:Issue 1(2018)
• Page Start: 262
• Page End: 269
• Publication Date: 2018-02
• Subjects: Parenteral nutrition -- Plant sterols -- Preterm infants -- Sterol metabolism; CAMP campesterol -- EN enteral nutrition -- LE lipid emulsion -- PHY phytosterols -- PN parenteral nutrition -- PNAC parenteral nutrition-associated cholestasis -- SITO sitosterol -- STIGM stigmasterol -- VLBW very low birth weight -- VO vegetable oil; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2016.12.022
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background: Phytosterols in vegetable oil (VO)-based lipid emulsions (LE) likely contribute to parenteral nutrition-associated cholestasis (PNAC) in preterm infants. No characterization of plasma phytosterol half-lives has been done in very low birth weight (VLBW) preterm infants receiving parenteral nutrition (PN) with LE. Methods: In a prospective cohort study, 45 VLBW preterm infants who received PN underwent serial blood sample measurements of sitosterol (SITO), campesterol (CAMP), and stigmasterol (STIGM). Plasma phytosterol half-lives were calculated from the phytosterol concentrations–decay curves by using a single-compartment model. Results: After the stop of the intravenous LE, study infants had significantly lower plasma total CAMP, STIGM and SITO concentrations. The decay of plasma phytosterol concentrations was monoexponential. Half-life of plasma total CAMP, STIGM and SITO was 13.5 ± 6.9, 10.3 ± 4.5 and 10.3 ± 4.0 days, respectively. Plasma phytosterol half-lives did not correlate with gestational age, birth weight, cumulative phytosterol intakes and plasma conjugated bilirubin. Conclusion: VLBW preterm infants on PN with LE had rather long plasma phytosterol half-lives similar to hypercholesterolemic adults and phytosterolemic homozygotes patients. We speculate that the accumulation of phytosterols could contribute to their vulnerability to PNAC. Clinical trial registry: The Ethics Committee of Marche-Italy (DG/469);www.clinicaltrials.gov (identification numberNCT02758834 ).