Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics. (May 2019)

• Record Type: Journal Article
• Authors: Burnett, Christina L.; Boyer, Ivan; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Gill, Lillian J.; Heldreth, Bart
• Is Part Of: International journal of toxicology. Volume 38:Number 1(2019)Supplement
• Page Start: 70S
• Page End: 84S
• Publication Date: 2019-05
• Subjects: methylisothiazolinone -- cosmetics -- safety; Toxicology -- Periodicals; 615.9005
• DOI: 10.1177/1091581819838792
• Languages: English
• ISSNs: 1091-5818

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.