Characteristics of patients with increasing COPD assessment test scores within 3 years. (October 2017)

• Record Type: Journal Article
• Authors: Irie, Hidehiro; Chubachi, Shotaro; Sato, Minako; Tsutsumi, Akihiro; Nakachi, Ichiro; Miyao, Naoki; Nishio, Kazumi; Nakamura, Hidetoshi; Asano, Koichiro; Betsuyaku, Tomoko
• Is Part Of: Respiratory medicine. Volume 131(2017)
• Page Start: 101
• Page End: 108
• Publication Date: 2017-10
• Subjects: COPD -- Emphysema -- Quality of life; COPD chronic obstructive pulmonary disease -- CAT COPD assessment test -- ΔCAT rate of change in CAT -- SGRQ St. George's Respiratory Questionnaire -- ΔSGRQ rate of change in SGRQ -- FEV1 forced expiratory volume in one second -- %FEV1 ratio of predicted FEV1 -- GOLD The Global Initiative for Chronic Obstructive Lung Disease -- mMRC the modified British Medical Research Council -- K-CCR the Keio COPD Comorbidity Research -- LAA% ratio of low attenuation area -- WA% ratio of airway wall area -- SF-36 medical outcomes study short-form 36-item -- ICS inhaled corticosteroids -- LAMA long-acting muscarinic antagonist -- LABA long-acting β2 agonist -- ΔSF-36 rate of change in SF-36 -- GERD gastroesophageal reflux disease -- BMI body mass index -- FVC forced vital capacity -- LTOT long-term oxygen therapy -- HAD-A seven items for anxiety of hospital anxiety and depression -- HAD-D seven items for depression of hospital anxiety and depression -- SD standard deviation; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2017.08.012
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a subjective measure of quality of life. The aim of this study was to examine the characteristics of COPD patients with increasing CAT scores within 3 years. Methods: Keio University and its affiliate hospitals conducted an observational COPD cohort study over 3 years. St. George's Respiratory Questionnaire (SGRQ) and CAT were completed at baseline and annually thereafter. Patients who had at least 3 CAT scores were included (n = 315). The ΔCAT score/year and ΔSGRQ score/year were calculated by the slope between each of the measures and the date of measurement. Results: The median ΔCAT score/year was 0.4, and ΔCAT score/year was significantly correlated with ΔSGRQ total score/year. Using an annual cut-off CAT score of +2 points, patients who deteriorated (n = 79) were older, had lower %FEV1, and more severe emphysema on computed tomography scan at baseline than patients who did not deteriorate. The baseline value was not a determinant of subsequent changes in the CAT score. Longitudinal changes in the CAT score were positively correlated with those in the SGRQ score. Conclusions: Old age and severe COPD, not the CAT score at one time point, predicted worsening quality of life. Highlights: Characteristics of COPD patients with increasing CAT scores within 3 years was investigated. Patients who deteriorated CAT scores were older, had lower %FEV1, and more severe emphysema. Baseline CAT value was not a determinant of subsequent changes in the CAT score. Longitudinal changes in the CAT score were positively correlated with those in the SGRQ score.