Pregnancy urinary bisphenol-A concentrations and glucose levels across BMI categories. (April 2018)

• Record Type: Journal Article
• Authors: Bellavia, Andrea; Cantonwine, David E.; Meeker, John D.; Hauser, Russ; Seely, Ellen W.; McElrath, Thomas F.; James-Todd, Tamarra
• Is Part Of: Environment international. Volume 113(2018)
• Page Start: 35
• Page End: 41
• Publication Date: 2018-04
• Subjects: BPA Bisphenol-A -- GDM gestational diabetes mellitus -- SG specific gravity -- IGT impaired glucose tolerance -- Q quartiles; Bisphenol-A -- Gestational diabetes -- Body mass index -- Glucose -- Pregnancy; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2018.01.012
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background: Pregnancy exposure to bisphenol-A (BPA) may be associated with gestational diabetes (GDM), but evidence from human studies is limited. Moreover, adiposity is associated with both higher BPA concentrations and GDM risk, and may act as a confounder or an effect modifier of the association. Methods: We included 350 term births from the Lifecodes pregnancy cohort (Boston, MA), who had 1st and 2nd trimester measures of urinary BPA concentrations available. BPA measures were SG-adjusted and categorized into quartiles (Q). Multivariable-adjusted linear regressions were used to determine the association between BPA, at both 1st and 2nd trimester, and glucose, in the overall population and by categories of 1st trimester BMI. Results: No clear associations were seen between BPA and glucose levels in the overall population. From stratified analyses there was suggestive evidence of effect modification by maternal 1st trimester BMI, with significant associations observed among obese/overweight participants (1st trimester BPA concentrations for Q3 vs Q1: adj.β = 14.1 mg/dL; 95% CI: 1.5, 26.6) (2nd trimester BPA concentrations for Q2 vs Q1: adj. β = 16.9 mg/dL; 95% CI: 2.6, 31.2). Conclusion: No associations were found between BPA and glucose levels in the overall population. However, moderately high BPA concentrations were associated with increased glucose levels among overweight/obese women—a subgroup at high-risk of elevated glucose levels in pregnancy. Highlights: Bisphenol-A (BPA) is an endocrine disrupting chemical that can lead to insulin resistance. Few studies have evaluated its association with gestational diabetes, with inconclusive results. We found pregnancy urinary BPA to be associated with higher glucose levels among overweight/obese women No associations were seen between BPA and glucose levels for normal or underweight women.