Traffic related air pollution and development and persistence of asthma and low lung function. (April 2018)

• Record Type: Journal Article
• Authors: Bowatte, Gayan; Lodge, Caroline J.; Knibbs, Luke D.; Erbas, Bircan; Perret, Jennifer L.; Jalaludin, Bin; Morgan, Geoffrey G.; Bui, Dinh S.; Giles, Graham G.; Hamilton, Garun S.; Wood-Baker, Richard; Thomas, Paul; Thompson, Bruce R.; Matheson, Melanie C.; Abramson, Michael J.; Walters, E. Haydn; Dharmage, Shyamali C.
• Is Part Of: Environment international. Volume 113(2018)
• Page Start: 170
• Page End: 176
• Publication Date: 2018-04
• Subjects: TRAP Traffic Related Air Pollution -- TAHS Tasmanian Longitudinal Health Study -- RHINE Respiratory Health in Northern Europe -- ECRHS European Community Respiratory Health Survey -- ESCAPE European Study of Cohorts for Air Pollution Effects -- PM10 particulate matter <10 μm in diameter -- PM2.5 particulate matter <2.5 μm in diameter -- COPD Chronic Obstructive Pulmonary Disease -- LUR Land Use Regression -- ATS American Thoracic Society -- ERS European Respiratory Society -- FEV1 Forced Expiratory Volume in 1 s -- FVC Forced Vital Capacity -- DAG Directed Acyclic Graph -- UFP Ultrafine Particles; Air pollution -- Asthma -- Lung function -- Cohort studies; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2018.01.028
• Languages: English
• ISSNs: 0160-4120

Abstract

Abstract: Background and aims: Traffic Related Air Pollution (TRAP) exposure is known to exacerbate existing respiratory diseases. We investigated longer term effects of TRAP exposure for individuals with or without existing asthma, and with or without lower lung function. Methods: Associations between TRAP exposure and asthma (n = 689) and lung function (n = 599) were investigated in the prospective Tasmanian Longitudinal Health Study (TAHS). TRAP exposure at age 45 years was measured using two methods based on residential address: mean annual NO2 exposure; and distance to nearest major road. Adjusted multinomial logistic regression was used to model the association between exposure to TRAP at 45 years and changes in asthma and lung function, using three follow ups of TAHS (45, 50 and 53 years). Results: For those who never had asthma by 45, living &lt;200 m from a major road was associated with increased odds of new asthma that persisted from 50 to 53 years (adjusted Odds Ratio [aOR] 5.20; 95% CI 1.07, 25.4). Asthmatic participants at 45 had an increased risk of persistent asthma up to 53 years if they were living &lt;200 m from a major road, compared with asthmatic participants living &gt;200 m from a major road (aOR = 5.21; 95% CI 1.54, 17.6). Conclusion: For middle aged adults, living &lt;200 m for a major road (a marker of TRAP exposure) influences both the development and persistence of asthma. These findings have public health implications for asthma prevention strategies in primary and secondary settings. Highlights: Living closer to major roads associated with incidence and persistence of asthma Recall of asthma by adults can introduce significant bias to the results obtained NO2 exposure modestly associated with incidence of asthma