Gadolinium-chelate functionalized bismuth nanotheranostic agent for in vivo MRI/CT/PAI imaging-guided photothermal cancer therapy. (March 2018)

• Record Type: Journal Article
• Authors: Wu, Bo; Lu, Shu-Ting; Yu, Hui; Liao, Ru-Fang; Li, Huan; Lucie Zafitatsimo, B.V.; Li, Yu-Shuang; Zhang, Ying; Zhu, Xiao-Lei; Liu, Hong-Guang; Xu, Hai-Bo; Huang, Shi-Wen; Cheng, Zhen
• Is Part Of: Biomaterials. Volume 159(2018)
• Page Start: 37
• Page End: 47
• Publication Date: 2018-03
• Subjects: Pure bismuth -- MR imaging -- CT -- Photoacoustic imaging -- Photothermal therapy -- Theranostics; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2017.12.022
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Multifunctional nanomaterials with simple structure and good biosafety, integrating multimodal imaging and therapeutic functions, can facilitate the development of clinical cancer treatments. Here, a simple but powerful pure bismuth based nanoparticle (Gd-PEG-Bi NPs) was developed from pure Bi NPs and gadolinium-diethylenetriaminepentaacetic acid-bis-tetradecylamide, which not only shows high quality MRI/CT/PAI triple-modal imaging, but can also be a potent photothermal therapy agent under the guidance of the triple-modal imaging. The Gd-PEG-Bi NPs showed good stability and excellent biocompatibility. In vitro and in vivo study demonstrated that Gd-PEG-Bi NPs have ultrahigh X-ray attenuation coefficient, short T1 relaxation time in MRI, and strong PAI signal. Following the imaging diagnosis, the excellent light-to-heat conversion efficiency of Gd-PEG-Bi NPs was capable of suppressing the tumor growth effectively under near-infrared laser radiation in vivo . Such multifunctional nanoparticles were ideal candidates for cancer diagnosis and treatment. Graphical abstract: Image Highlights: A simple and powerful pure bismuth based nanoparticle was developed. The pure bismuth based nanoparticle showed excellent light-to-heat conversion efficiency. The bismuth nanoparticle can provide MRI/CT/PAI multimodal imaging and photothermal therapy.