Long non-coding and endogenous retroviral RNA levels are associated with proinflammatory cytokine mRNA expression in peripheral blood cells: Implications for schizophrenia. (April 2018)

• Record Type: Journal Article
• Authors: Melbourne, Jennifer K.; Chase, Kayla A.; Feiner, Benjamin; Rosen, Cherise; Sharma, Rajiv P.
• Is Part Of: Psychiatry research. Volume 262(2018)
• Page Start: 465
• Page End: 468
• Publication Date: 2018-04
• Subjects: lncRNA -- HERV-W -- Cytokine; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.09.025
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Recent research indicates that the expression of long non-coding and endogenous retroviral RNAs is coordinated with the activity of immune molecules often dysregulated in schizophrenia. We measured the expression of TMEVPG1, NRON, HERV-W env and HERV-W gag in blood cells from participants with schizophrenia and controls. We report that a) expression levels of these non-coding RNAs are correlated with proinflammatory cytokine mRNA expression in all participants, b) HERV-W transcripts are negatively correlated with atypical antipsychotic use in participants with schizophrenia, and c) that these RNAs are transcribed in response to proinflammatory stimuli in a THP-1 monocyte cell line. Highlights: Expression of lncRNAs and cytokines are correlated in human blood cells. Expression of HERV transcripts and cytokines are correlated in human blood cells. These lncRNAs/HERVs are responsive to inflammatory stimuli in a monocyte cell line.