Cytomegalovirus induced hemophagocytic lymphocytic histiocytosis in two pediatric patients with acute lymphoblastic leukemia. (2017)

• Record Type: Journal Article
• Authors: Waddell, Benjamin; Razzouk, Bassem; Willey, Emily; Belcher, Chris
• Is Part Of: IDCases. Volume 9(2017)
• Page Start: 116
• Page End: 118
• Publication Date: 2017
• Subjects: HLH hemophagocytic lymphocytic histiocytosis -- CMV cytomegalovirus -- ALL acute lymphoblastic leukemia; Hemophagocytic lymphohistiocytosis -- Cytomegalovirus -- Acute lymphoblastic leukemia -- Pediatric infections; Communicable diseases -- Periodicals; Communicable Diseases -- Case Reports; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.1016/j.idcr.2017.07.003
• Languages: English
• ISSNs: 2214-2509

Abstract

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare inflammatory condition with tissue destruction due to abnormal immune activation. We present a series of 2 cases of cytomegalovirus-induced HLH in children during maintenance chemotherapy for acute lymphoblastic leukemia. These cases emphasize the importance of considering secondary HLH in this high-risk subset of pediatric patients.