Depression and anxiety both associate with serum level of hs-CRP: A gender-stratified analysis in a population-based study. (July 2017)

• Record Type: Journal Article
• Authors: Tayefi, Maryam; Shafiee, Mojtaba; Kazemi-Bajestani, Seyyed Mohammad Reza; Esmaeili, Habibolah; Darroudi, Susan; Khakpouri, Samaneh; Mohammadi, Maryam; Ghaneifar, Zahra; Azarpajouh, Mahmoud Reza; Moohebati, Mohsen; Heidari-Bakavoli, Alireza; Parizadeh, Mohammad Reza; Nematy, Mohsen; Safarian, Mohammad; Ebrahimi, Mahmoud; Ferns, Gordon A.; Mokhber, Naghmeh; Ghayour-Mobarhan, Majid
• Is Part Of: Psychoneuroendocrinology. Volume 81(2017)
• Page Start: 63
• Page End: 69
• Publication Date: 2017-07
• Subjects: High-sensitivity C-reactive protein -- Inflammation -- Obesity -- Smoking -- Depression -- Anxiety; Psychoneuroendocrinology -- Periodicals; Endocrinology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Neuropsychoendocrinologie -- Périodiques; 616.8
• DOI: 10.1016/j.psyneuen.2017.02.035
• Languages: English
• ISSNs: 0306-4530

Abstract

Highlights: Depression and anxiety disorders are associated with elevated levels of hs-CRP, especially among men. Depression and anxiety disorders have a significant positive association with smoking in both sexes. Depression and anxiety disorders have a significant positive association with obesity; only among women. Abstract: Background: Depression and anxiety are two important mood disorders that are frequently associated with chronic diseases such as cardiovascular diseases (CVDs). Hyper-inflammation is related to both CVDs and psychological conditions such as depression and anxiety. Therefore, inflammation may partially explain the relationship between depression and cardiovascular disease. Objective: The objective of this study was to perform a gender-stratified examination of the association between symptoms of depression/anxiety disorders and serum hs-CRP and inflammation linked conditions in a large Iranian population. Methods: Symptoms of depression and anxiety disorders and serum hs-CRP levels were measured in 9759 participants (40% males and 60% females) aged 35–65 years, enrolled in a population-based cohort (MASHAD) study in north-eastern Iran. Symptoms of depression and anxiety were evaluated with Beck Depression and Anxiety Inventories. According to the scores of depression and anxiety, individuals were categorized into four groups of no or minimal, low, moderate and severe categories. Results: The median serum hs-CRP concentration increased with increasing severity of depression and anxiety disorders. Male participants with severe depression had significantly higher levels of hs-CRP (p < 0.001); however, this relationship was less marked among women (p = 0.04). Subjects with severe anxiety also had significantly higher levels of hs-CRP (p < 0.001). Moreover, women with severe depression and anxiety had higher BMI. There was also a positive association between current smoking habit and depression/anxiety disorders. Conclusion: Depression and anxiety disorders are associated with elevated levels of hs-CRP, particularly among men. Also, there is a significant positive association between depression/anxiety disorders and inflammation linked conditions such as smoking and obesity; however, in the case of obesity this association is only present in women.