17β-Estradiol inhibits estrogen binding protein-mediated hypha formation in Candida albicans. (August 2017)

• Record Type: Journal Article
• Authors: Kurakado, Sanae; Kurogane, Rie; Sugita, Takashi
• Is Part Of: Microbial pathogenesis. Volume 109(2017)
• Page Start: 151
• Page End: 155
• Publication Date: 2017-08
• Subjects: Candida albicans -- Estrogen binding protein -- 17β-estradiol -- Yeast-to-hypha transition; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2017.05.038
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Candida albicans is one of the most prevalent and clinically important fungal pathogens. The ability to change form depending on environmental stress is an important microbial virulence factor. A survey of compounds that inhibit this morphological change identified various steroids, including 17β-estradiol. Interestingly, C. albicans has proteins capable of binding to steroids, including estrogen binding protein (Ebp1). Estrogens regulate cell differentiation and proliferation in humans through estrogen receptor proteins. To determine whether EBP1 regulates a virulence factor, we investigated the effect of 17β-estradiol on the morphological transition of C. albicans using an ebp1 deletion mutant. Treatment with 10 μg/mL of 17β-estradiol inhibited hypha formation, whereas its effect on the ebp1 deletion mutant was decreased compared to that on the wild-type and revertant strains. These data suggest a new pathway for the yeast-to-hypha transition via EBP1 in C. albicans . Highlights: Candida albicans has an estrogen binding protein (Ebp1). 17β-Estradiol inhibits hypha formation in C. albicans. The effect on the ebp1 deletion mutant is decreased compared to that on the WT.